Recent publications 


Jung EH, Meyers DJ, Bosch J, Casadevall A. Novel Antifungal Compounds Discovered in Medicines for Malaria Venture's Malaria Box. mSphere. 2018 Mar 14;3(2). pii: e00537-17. doi: 10.1128/mSphere.00537-17. eCollection 2018 Mar-Apr. PubMed PMID: 29564402; PubMed Central PMCID: PMC5853493.


Villa S, Legnani L, Colombo D, Gelain A, Lammi C, Bongiorno D, Ilboudo DP, McGee KE, Bosch J, Grazioso G. Structure-based drug design, synthesis and biological assays of P. falciparum Atg3-Atg8 protein-protein interaction inhibitors. J Comput Aided Mol Des. 2018 Mar;32(3):473-486. doi:10.1007/s10822-018-0102-5. Epub 2018 Jan 30. PubMed PMID: 29383466.


Boucher LE, Hopp CS, Muthinja JM, Frischknecht F, Bosch J. Discovery of Plasmodium (M)TRAP-Aldolase Interaction Stabilizers Interfering with Sporozoite Motility and Invasion. ACS Infect Dis. 2018 Feb 19. doi:10.1021/acsinfecdis.7b00225. [Epub ahead of print] PubMed PMID: 29411968.


Parker ML, Ramaswamy R, van Gordon K, Powell CJ, Bosch J, Boulanger MJ. The structure of Plasmodium falciparum 3D7_0606800 reveals a bi-lobed architecture that supports re-annotation as a Venus Flytrap protein. Protein Sci. 2017 Sep;26(9):1878-1885. doi: 10.1002/pro.3218. Epub 2017 Jul 26. PubMed PMID:28681555; PubMed Central PMCID: PMC5563136.


Bosch J. PPI inhibitor and stabilizer development in human diseases. Drug Discov Today Technol. 2017 Jun;24:3-9. doi:10.1016/j.ddtec.2017.10.004. Review. PubMed PMID: 29233297.


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We have a combined expertise of 30 years in Biochemistry and Molecular Biology, Protein production, X-ray crystallography, Surface Plasmon Resonance, Assay development and implementation, Computational Biology and in silico docking studies.

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