We offer a range of consulting services, all designed to help your team reach its potential.
We have a combined expertise of 40 years in Biochemistry and Molecular Biology, Protein production, X-ray crystallography, Surface Plasmon Resonance, Assay development and implementation, Computational Biology and in silico docking studies.
We work with Biotech startup as well as academic institutions.
Jürgen Bosch, PhD, MBA
Co-Founder & CEO
we believe in customized Solutions to a problem.
our approach
Gundula Bosch, PHD
Co-FoundeR & Co-Owner
Business Consulting in Drug discovery
Recent publications
Leung AKL.,Griffin DE., Bosch J., Fehr AR, The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses. Pathogens 2022, 11(1), 94; https://doi.org/10.3390/pathogens11010094
Shen YA, Jung J, Shimberg GD, Hsu FC, Rahmanto YS, Gaillard SL, Hong J, Bosch J, Shih IM, Chuang CM, Wang TL. Development of small molecule inhibitors targeting PBX1 transcription signaling as a novel cancer therapeutic strategy. iScience. 2021;24(11):103297. Epub 2021/11/25. doi: 10.1016/j.isci.2021.103297. PubMed PMID: 34816098; PMCID: PMC8591422.
Dasovich M, Zhuo J, Goodman JA, Thomas A, McPherson RL, Jayabalan AK, Busa VF, Cheng SJ, Murphy BA, Redinger KR, Alhammad YMO, Fehr AR, Tsukamoto T, Slusher BS, Bosch J, Wei H, Leung AKL.High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain. ACS Chem Biol. 2021. Epub 2021/12/15. doi: 10.1021/acschembio.1c00721. PubMed PMID: 34904435; PMCID: PMC8691451.
Colón-Lorenzo EE, Colón-López DD, Vega-Rodríguez J, Dupin A, Fidock DA, Baerga-Ortiz A, Ortiz JG, Bosch J, Serrano AE. Structure-Based Screening of Plasmodium berghei Glutathione S-Transferase Identifies CB-27 as a Novel Antiplasmodial Compound.Front Pharmacol. 2020;11:246. Epub 2020/04/08. doi: 10.3389/fphar.2020.00246. PubMed PMID: 32256353; PMCID: PMC7090221.
Gawenis LR, Hodges CA, McHugh DR, Valerio DM, Miron A, Cotton CU, Liu J, Walker NM, Strubberg AM, Gillen AE, Mutolo MJ, Kotzamanis G, Bosch J, Harris A, Drumm ML, Clarke LL. A BAC Transgene Expressing Human CFTR under Control of Its Regulatory Elements Rescues Cftr Knockout Mice.Sci Rep. 2019;9(1):11828. Epub 2019/08/16. doi: 10.1038/s41598-019-48105-4. PubMed PMID: 31413336; PMCID: PMC6694137.
Jung EH, Meyers DJ, Bosch J, Casadevall A. Novel Antifungal Compounds Discovered in Medicines for Malaria Venture's Malaria Box. mSphere. 2018 Mar 14;3(2). pii: e00537-17. doi: 10.1128/mSphere.00537-17. eCollection 2018 Mar-Apr. PubMed PMID: 29564402; PubMed Central PMCID: PMC5853493.
Villa S, Legnani L, Colombo D, Gelain A, Lammi C, Bongiorno D, Ilboudo DP, McGee KE, Bosch J, Grazioso G. Structure-based drug design, synthesis and biological assays of P. falciparum Atg3-Atg8 protein-protein interaction inhibitors. J Comput Aided Mol Des. 2018 Mar;32(3):473-486. doi:10.1007/s10822-018-0102-5. Epub 2018 Jan 30. PubMed PMID: 29383466.
Saraiva RG, Huitt-Roehl CR, Tripathi A, Cheng YQ, Bosch J, Townsend CA, Dimopoulos G. Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin.Sci Rep. 2018;8(1):6176. Epub 2018/04/20. doi: 10.1038/s41598-018-24296-0. PubMed PMID: 29670144; PMCID: PMC5906607.
Powell CJ, Ramaswamy R, Kelsen A, Hamelin DJ, Warshaw DM, Bosch J, Burke JE, Ward GE, Boulanger MJ. Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii. Proc Natl Acad Sci U S A. 2018;115(45):E10548-e55. Epub 2018/10/24. doi: 10.1073/pnas.1811167115. PubMed PMID: 30348763; PMCID: PMC6233092.
Boucher LE, Hopp CS, Muthinja JM, Frischknecht F, Bosch J. Discovery of Plasmodium (M)TRAP-Aldolase Interaction Stabilizers Interfering with Sporozoite Motility and Invasion. ACS Infect Dis. 2018 Feb 19. doi:10.1021/acsinfecdis.7b00225. [Epub ahead of print] PubMed PMID: 29411968.
Parker ML, Ramaswamy R, van Gordon K, Powell CJ, Bosch J, Boulanger MJ. The structure of Plasmodium falciparum 3D7_0606800 reveals a bi-lobed architecture that supports re-annotation as a Venus Flytrap protein. Protein Sci. 2017 Sep;26(9):1878-1885. doi: 10.1002/pro.3218. Epub 2017 Jul 26. PubMed PMID:28681555; PubMed Central PMCID: PMC5563136.
Bosch J. PPI inhibitor and stabilizer development in human diseases. Drug Discov Today Technol. 2017 Jun;24:3-9. doi:10.1016/j.ddtec.2017.10.004. Review. PubMed PMID: 29233297.